News - Parc de Salut Mar News Houdini 2 ( Finded Notch self-inhibition keeps haematopoietic stem cells from differentiate A collaborative effort led by Dr. Anna Bigas, from the Hospital del Mar Research Institute and Josep Carreras Leukaemia Research Institute, found that the population of haematopoietic stem cells (HSC) responsible for the generation and self-renewal of the blood and immune system keeps a long-term undifferentiated state thanks to its ability to physically block its own NOTCH1 receptor through the expression of JAGGED1, a specific NOTCH activator. Authors hypothesise that the lack of this previously unknown mechanism might be the cause for the poor performance of current approaches to generate haematopoietic stem cells from induced pluripotent stem cells for regenerative medicine.

Thu, 22 Feb 2024 17:07:16 +0000 0
Artificial intelligence tool developed to predict multiple sclerosis patients' evolution This is an international collaborative work coordinated by the Hospital del Mar Research Institut and the Hospital Clínic-IDIBAPS, published in the Journal of Neurology.

This new tool may make it possible to adapt the monitoring and treatment of patients to their future evolution, opting for the most effective, but with more possible side effects in those with worse prognosis.

The exact factors behind the progression of disability in multiple sclerosis, a disease with great heterogeneity, are unknown, which is why it is so important to have tools of this type.

Wed, 21 Feb 2024 09:23:14 +0000 0
A new antibody manages to block all variants of SARS-CoV-2 in preclinical models It is a monoclonal antibody with both prophylactic and therapeutic action, isolated from blood samples of a patient infected with SARS-CoV-2 during the first wave of the pandemic.

The antibody has been designed and developed by researchers from the Hospital del Mar Research Institute, the IrsiCaixa AIDS Research Institute, the National Center for Biotechnology, and the Center for Genomic Regulation.

This new treatment has been patented pending commercial development. The results of the work have been published in Nature Communications journal.

Fri, 09 Feb 2024 12:01:34 +0000 0
The analysis of biological networks allows understanding the complexity of multiple sclerosis An international study has used a computational biology tool that, by analysing a multitude of biological data from multiple sclerosis patients ranging from genetic information to the whole organism, reveals the relationship between elements of different biological scales and improves our knowledge and the diagnosis of the disease.

Thu, 08 Feb 2024 13:15:17 +0000 0
High blood omega-3 levels are associated with lower risk of dementia and Alzheimer's disease This is revealed by the largest observational study in this field carried out to date in the world. It is published in the journal Nutrients.

The work is based on data from the UK Biobank database and has made it possible to analyze information from more than 260,000 people. Its conclusions may allow a more detailed definition of future studies on omega-3 supplementation for the prevention of dementia.

The potential benefits of these fatty acids are maximal in men over 60 and in dementias other than Alzheimer's disease.

Tue, 30 Jan 2024 08:23:54 +0000 0
Dr. Helena Tizón is the new director of the Comprehensive Plan for Cardiovascular Diseases in Catalonia, focusing on cardiovascular diseases The Minister of Health officially announced the cardiologist's appointment from Hospital del Mar and researcher at the Hospital del Mar Research Institute last December. Dr. Tizón replaces Dr. Josepa Mauri from Hospital Germans Trias i Pujol, who held this position for the past 8 years.

Thu, 18 Jan 2024 13:27:07 +0000 0
Discovering a Defective Class of Neurons in the Brains of Individuals with Schizophrenia Functional alterations in the brains of individuals with this condition coincide with the distribution of these neurons in the same brain.

These neurons are responsible for filtering external information reaching the brain. Their functioning is altered in individuals with schizophrenia, which explains the majority of their symptoms.

This discovery is the first time that this alteration can be identified as a possible origin of schizophrenic symptoms, and it opens the door to seeking new targeted treatments with fewer patient side effects.

Tue, 09 Jan 2024 12:54:25 +0000 0
The smallpox vaccine effectively induces immunity against monkeypox virus infection in people with HIV An observational study conducted by researchers from Pompeu Fabra University and Hospital del Mar determines that the intradermal administration of the JYNNEOS vaccine against smallpox induces an efficient immune response that should protect people living with HIV from contracting the monkeypox virus.

Thu, 28 Dec 2023 08:04:18 +0000 0
The results of research into a new oral treatment for COVID-19 has been published A clinical trial carried out by Hospital del Mar, Pompeu Fabra University, the Health Research Institute of Santiago de Compostela and the Pere Virgili Health Park investigated the efficacy and safety of a medicine for outpatients with COVID-19.

The treatment acts on the replication mechanism of SARS-CoV-2, the virus responsible for the disease, and reduces the severity and duration of some of the symptoms. In addition, it can be useful to treat the different mutations detected.

Were its usefulness for treating COVID-19 confirmed, it would be one of the first drugs that could be given to primary care patients to prevent their condition from worsening and requiring hospital admission.

Tue, 19 Dec 2023 10:41:50 +0000 0
The presence of professionals from the Hospital del Mar increases in Stanford University's World's Top 2% Scientist ranking The Hospital del Mar and the Hospital del Mar Research Institute have achieved a record number of professionals, with 33 present in the new edition of the World's Top 2% Scientist, a ranking compiled by Stanford University in the United States.

Wed, 13 Dec 2023 09:30:34 +0000 0